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New beauveriolides produced by amino acid-supplemented fermentation of Beauveria sp. FO-6979.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2004 Jan; Vol. 57 (1), pp. 1-9. - Publication Year :
- 2004
-
Abstract
- Five new beauveriolides were isolated from the acetone extracts of Beauveria sp. FO-6979 mycelia fermented in amino acid-supplemented media. The structures were elucidated by spectroscopic studies including NMR experiments and chemical degradation. All the beauveriolides are cyclodepsipeptides consisting of one 3-hydroxy-4-methyl fatty acid, two L-amino acids and one D-amino acid in common. Beauveriolide VII with the structure of cyclo-[3-hydroxy-4-methyloctanoyl-L-phenylalanyl-L-alanyl-D-valyl] inhibited lipid droplet formation and cholesteryl ester synthesis in macrophages, but the other beauveriolides showed only slight or almost no effect on lipid droplet formation.
- Subjects :
- Animals
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents isolation & purification
Anti-Bacterial Agents pharmacology
Ascomycota chemistry
Cholesterol Esters metabolism
Chromatography, Gel
Fermentation
Lipid Metabolism
Macrophages, Peritoneal drug effects
Mice
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Peptides, Cyclic isolation & purification
Peptides, Cyclic pharmacology
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Amino Acids metabolism
Ascomycota metabolism
Depsipeptides
Peptides, Cyclic biosynthesis
Peptides, Cyclic chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0021-8820
- Volume :
- 57
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 15032479
- Full Text :
- https://doi.org/10.7164/antibiotics.57.1