Back to Search
Start Over
Tissue angiotensin-converting enzyme in imposed and physiological flow-related arterial remodeling in mice.
- Source :
-
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2004 May; Vol. 24 (5), pp. 892-7. Date of Electronic Publication: 2004 Mar 18. - Publication Year :
- 2004
-
Abstract
- Objective: To test whether membrane-bound angiotensin I-converting enzyme (t-ACE) is involved in arterial remodeling, we applied unilateral carotid artery (CA) ligation and studied uterine arteries (UA) before, during, and after pregnancy in t-ACE-/- and t-ACE+/+ mice. RESULTS- In CA of t-ACE-/- mice, blood pressure, outer diameter (D), and medial cross-sectional area (mCSA) were reduced, whereas blood flow (BF) and the number of medial cells (mC) were not modified. In the ligated CA, mCSA and number of mC were increased while outer D and distensibility were reduced. These changes were significantly less pronounced in t-ACE-/- than t-ACE+/+ mice. In UA of t-ACE-/- mice, D was larger and mCSA was unaltered. At term pregnancy, D and mCSA of the UA were reversibly increased. Structural changes of UA during and after pregnancy were comparable in both strains.<br />Conclusions: t-ACE contributes to arterial structure and remodeling. It plays a major role in hyperplastic inward remodeling of the CA imposed by blood flow cessation, but it is not essential for outward hypertrophic and subsequent inward hypotrophic remodeling of the UA during and after pregnancy.
- Subjects :
- Alleles
Angiotensin II physiology
Animals
Arteries anatomy & histology
Arteries enzymology
Carotid Arteries pathology
Female
Hyperplasia
Hypertrophy
Ligation
Male
Membrane Proteins deficiency
Membrane Proteins genetics
Mice
Mice, Inbred C57BL
Peptidyl-Dipeptidase A chemistry
Peptidyl-Dipeptidase A deficiency
Peptidyl-Dipeptidase A genetics
Postpartum Period
Pregnancy
Protein Structure, Tertiary
Sequence Deletion
Stress, Mechanical
Carotid Arteries enzymology
Hemorheology
Membrane Proteins physiology
Peptidyl-Dipeptidase A physiology
Uterus blood supply
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4636
- Volume :
- 24
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Arteriosclerosis, thrombosis, and vascular biology
- Publication Type :
- Academic Journal
- Accession number :
- 15031129
- Full Text :
- https://doi.org/10.1161/01.ATV.0000126374.60073.3d