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[Episodic disseminated inflammation of the central nervous system. Case mix review over a 13 year period].
- Source :
-
Revista de neurologia [Rev Neurol] 2004 Mar 1-15; Vol. 38 (5), pp. 405-10. - Publication Year :
- 2004
-
Abstract
- Introduction: Episodic disseminated inflammation of the central nervous system (CNS) presents in processes that are difficult to differentiate, such as acute disseminated encephalomyelitis (ADE) and its multiphasic variants, and multiple sclerosis (MS). Magnetic resonance imaging allows these problems to be identified more frequently than in the past.<br />Patients and Methods: We carried out a retrospective study of the cases of episodic disseminated inflammation of the CNS, according to clinical features and compatible neuroimaging, at the Neuropaediatric Unit of the Hospital Infantil Miguel Servet, between May 1990 and August 2003.<br />Results: Of the 6777 children evaluated over this period, 10 met the eligibility criteria, with a minimum age at onset of 2 years and 2 months. In four cases there was a history of an infectious process or vaccination. Clinical involvement was multisymptomatic, the most frequent being ataxia, dysmetry, tremor, drowsiness, paresis and cranial nerve involvement. Six of them had cerebrospinal fluid disorders and only two presented disorders in the fundus oculi. Five of them were given corticoid treatment. Progress was favourable, except in two cases: one due to the persistence of a corticoid dependent optical neuropathy and the other because of dyskinesia in the right hand.<br />Discussion: Diagnosis of ADE is established by signs of multifocal clinical involvement and neuroimaging, and depends on a compatible progression. Prognosis is generally good and corticoids seem to be effective, at least in shortening the time the clinical features last. It is not possible to completely differentiate it from MS, especially in recurring forms. Clinical and magnetic resonance controls must be carried out.
- Subjects :
- Adolescent
Child
Child, Preschool
Diagnosis, Differential
Diagnosis-Related Groups
Diphtheria-Tetanus-Pertussis Vaccine adverse effects
Disease Progression
Encephalomyelitis, Acute Disseminated cerebrospinal fluid
Encephalomyelitis, Acute Disseminated diagnosis
Encephalomyelitis, Acute Disseminated etiology
Female
Humans
Infections complications
Magnetic Resonance Imaging
Male
Multiple Sclerosis diagnosis
Poliovirus Vaccine, Oral adverse effects
Recurrence
Retrospective Studies
Spain epidemiology
Tetanus Toxoid adverse effects
Vaccination adverse effects
Encephalomyelitis, Acute Disseminated epidemiology
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0210-0010
- Volume :
- 38
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Revista de neurologia
- Publication Type :
- Academic Journal
- Accession number :
- 15029515