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Sleep-promoting properties of quetiapine in healthy subjects.
- Source :
-
Psychopharmacology [Psychopharmacology (Berl)] 2004 Jul; Vol. 174 (3), pp. 421-9. Date of Electronic Publication: 2004 Mar 17. - Publication Year :
- 2004
-
Abstract
- The aim of this study was to investigate the effects of quetiapine, an atypical antipsychotic, on polysomnographic sleep structure and subjective sleep quality. This double-blind, placebo-controlled, randomized cross-over study investigated the polysomnographic sleep structure and subjective sleep quality of 14 healthy male subjects given placebo, quetiapine 25 mg or quetiapine 100 mg. Volunteers were studied 3 times for 3 consecutive nights (N0, adaptation; N1, standard sleep conditions; N2, acoustic stress) 4 days apart. Treatment was administered orally 1 h before bedtime on nights 1 and 2. Quetiapine 25 mg and 100 mg significantly improved sleep induction and continuity under standard and acoustic stress conditions. Increases in total sleep time, sleep efficiency, percentage sleep stage 2 and subjective sleep quality were seen. A significant increase in periodic leg movements during sleep was observed with quetiapine 100 mg. The sleep-improving properties of quetiapine may be important in counteracting different aspects of psychopathology in schizophrenia and other disorders. These sleep-inducing and sleep-modifying properties are probably related to quetiapine's receptor-binding profile, including its antihistaminergic, antidopaminergic and antiadrenergic properties. Other mechanisms might be relevant as well and further investigation is required.
- Subjects :
- Acoustic Stimulation adverse effects
Adult
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Humans
Male
Multivariate Analysis
Polysomnography methods
Quetiapine Fumarate
Sleep physiology
Sleep Stages drug effects
Sleep Stages physiology
Sleep Wake Disorders drug therapy
Sleep Wake Disorders etiology
Surveys and Questionnaires
Antipsychotic Agents pharmacology
Dibenzothiazepines pharmacology
Sleep drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0033-3158
- Volume :
- 174
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 15029469
- Full Text :
- https://doi.org/10.1007/s00213-003-1759-5