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C Reactive protein, moderate alcohol consumption, and long term prognosis after successful coronary stenting: four year results from the GENERATION study.
- Source :
-
Heart (British Cardiac Society) [Heart] 2004 Apr; Vol. 90 (4), pp. 419-24. - Publication Year :
- 2004
-
Abstract
- Objectives: To determine the impact of moderate alcohol consumption on long term prognosis after successful coronary stenting, and whether it could be related to preprocedural plasma C reactive protein (CRP).<br />Design: Part of the prospectively designed GENERATION study which investigated the impact of several biochemical factors, including plasma CRP, on long term prognosis after coronary stenting.<br />Setting: Tertiary referral centre.<br />Patients: 483 consecutive patients with stable or unstable coronary artery disease who underwent successful coronary stenting and were followed for up to four years. Information about alcohol consumption was collected prospectively.<br />Interventions: Successful coronary stenting.<br />Main Outcome Measures: The incidence of the composite end point of readmission to hospital for unstable angina, non-fatal myocardial infarction, or cardiac death, whichever occurred first.<br />Results: By the end of follow up the incidence of the composite end point was 22.8%. Patients with a baseline plasma CRP concentration of < 0.68 mg/dl (defined by ROC analysis) did not show any difference in the composite end point (p = 0.9) or its components, regardless of the amount of alcohol consumed during follow up. However, among patients with plasma CRP concentration of > or = 0.68 mg/dl, those who drank moderately had a lower incidence of the composite end point (p < 0.001) or its components.<br />Conclusions: Moderate alcohol consumption may have a beneficial impact on the long term prognosis following successful coronary stenting. The extent of this effect is positively related to preprocedural inflammatory status. An anti-inflammatory action of moderate alcohol consumption cannot be excluded.
- Subjects :
- Alcohol Drinking blood
Angina, Unstable blood
Angina, Unstable mortality
Angina, Unstable surgery
Coronary Artery Disease blood
Coronary Artery Disease mortality
Female
Follow-Up Studies
Humans
Male
Middle Aged
Myocardial Infarction blood
Myocardial Infarction mortality
Myocardial Infarction surgery
Prognosis
Prospective Studies
Survival Analysis
Alcohol Drinking mortality
C-Reactive Protein analysis
Coronary Artery Disease surgery
Stents
Subjects
Details
- Language :
- English
- ISSN :
- 1468-201X
- Volume :
- 90
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Heart (British Cardiac Society)
- Publication Type :
- Academic Journal
- Accession number :
- 15020518
- Full Text :
- https://doi.org/10.1136/hrt.2003.016337