Back to Search
Start Over
CGH analysis shows genetic similarities and differences in atypical fibroxanthoma and undifferentiated high grade pleomorphic sarcoma.
- Source :
-
Anticancer research [Anticancer Res] 2004 Jan-Feb; Vol. 24 (1), pp. 19-26. - Publication Year :
- 2004
-
Abstract
- Background: Atypical fibroxanthoma (AFX) and undifferentiated high grade pleomorphic sarcoma (UpS) are histologically very similar, if not identical. However, they differ significantly in clinical outcome.<br />Materials and Methods: We used comparative genomic hybridization (CGH) to screen 24 AFX and 12 UpS for genomic alterations.<br />Results: DNA copy number changes were observed in 20/24 AFX and in all UpS. The most frequent alterations occurring with comparable frequency in both tumors were deletions on chromosomes 9p and 13q. We also detected statistically significant differences of genetic alterations between the two tumors concerning deletions on 1q, 3p, 5q, 11p, 11q, gains on 7q, 12q and high level gains on 5p and 11q.<br />Conclusion: Despite their very similar histology, AFX and UpS show clear differences in their genetic alterations. This might contribute to the different biological behavior of the two tumors. On the other hand the similarities in genetic alterations on chromosomes 9p and 13q might suggest a common pathogenetic pathway.
- Subjects :
- Adult
Aged
Aged, 80 and over
Chromosomes, Human, Pair 13 genetics
Chromosomes, Human, Pair 9 genetics
DNA, Neoplasm genetics
Female
Gene Dosage
Histiocytoma, Benign Fibrous pathology
Humans
Male
Middle Aged
Muscle Neoplasms genetics
Muscle Neoplasms pathology
Nucleic Acid Hybridization
Sarcoma pathology
Skin Neoplasms genetics
Skin Neoplasms pathology
Chromosome Aberrations
Histiocytoma, Benign Fibrous genetics
Sarcoma genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0250-7005
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 15015571