Back to Search
Start Over
[Study on in vitro dissolution rate of geniposide in huangqin qingfei dispersible tablet].
- Source :
-
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2003 Aug; Vol. 28 (8), pp. 721-3. - Publication Year :
- 2003
-
Abstract
- Objective: To study in vitro dissolution rate of geniposide in Huangqin Qingfei dispersible tablet.<br />Method: A reversed-phase HPLC method was developed for determination of geniposide. In vitro dissolution rates were compared between Huangqin Qingfei dispersible tablet and conventional tablet in the dissolution medium of pH 1.0, 2.85, 4.5, 6.8, and 8.0 accordingly. Zero-class model, single-index model, logarithm normal school model, and Weibull distributing model were used to simulate the dissolution curve.<br />Result: The dissolution rate of two tablets is not affected by pH so much, and they can dissolve within 5 to 10 minutes. Weibull distributing model is the best simulation for in vitro dissolution. Comparing with conventional tablet, dispersible tablet dissolve quickly and completely.<br />Conclusion: The in vitro dissolution rate of geniposide in Huangqin Qingfei dispersible tablet conforms to Weibull distributing model. The dispersible tablet is able to release rapidly.
- Subjects :
- Chromatography, High Pressure Liquid
Drug Combinations
Drugs, Chinese Herbal administration & dosage
Drugs, Chinese Herbal isolation & purification
Kinetics
Scutellaria chemistry
Solubility
Tablets chemistry
Time Factors
Drugs, Chinese Herbal chemistry
Gardenia chemistry
Iridoids analysis
Plants, Medicinal chemistry
Pyrans analysis
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-5302
- Volume :
- 28
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Publication Type :
- Academic Journal
- Accession number :
- 15015350