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Non-peptide alpha v beta 3 antagonists. Part 7: 3-Substituted tetrahydro-naphthyridine derivatives.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2004 Feb 23; Vol. 14 (4), pp. 1049-52. - Publication Year :
- 2004
-
Abstract
- A series of 3-substituted tetrahydro-[1,8]naphthyridine containing alpha(v)beta(3) antagonists was prepared. A comparison of their in vitro IC(50) values to the electron properties of the 3-substituents revealed a good linear Hammett correlation (rho=-1.96, R(2)=0.959). Electron-withdrawing groups at the 3-position of the tetrahydro-[1,8]naphthyridine decreased potency while electron-donating groups enhanced potency.
- Subjects :
- Adrenergic alpha-Antagonists chemical synthesis
Adrenergic beta-Antagonists chemical synthesis
Humans
Molecular Structure
Naphthyridines chemical synthesis
Structure-Activity Relationship
Adrenergic alpha-Antagonists pharmacology
Adrenergic beta-Antagonists pharmacology
Integrin alphaVbeta3 antagonists & inhibitors
Naphthyridines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 14
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 15013021
- Full Text :
- https://doi.org/10.1016/j.bmcl.2003.11.036