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Favourable results with a single autologous stem cell transplant following conditioning with busulphan and cyclophosphamide in patients with multiple myeloma.
- Source :
-
British journal of haematology [Br J Haematol] 2004 Mar; Vol. 124 (6), pp. 769-76. - Publication Year :
- 2004
-
Abstract
- Both single and tandem cycles of high dose therapy and autologous peripheral blood stem cell transplantation (ASCT) have been shown to improve survival in multiple myeloma (MM) patients. We report outcomes in 104 MM patients undergoing a single transplant after conditioning with a conventional myeloablative regimen, busulphan and cyclophosphamide. The patients were either in a first (71%), or subsequent remission (29%). Peripheral blood stem cells were mobilized using cyclophosphamide and granulocyte colony stimulating factor. The conditioning regimen consisted of busulphan 0.85 mg/kg given orally every 6 h (16 doses) and cyclophosphamide 60 mg/kg/d given intravenously for 2 d. The entire conditioning, transplant and post-transplant course were in the outpatient setting for 45% patients. At a median follow-up of 26 months (range 2-98 months), the median overall and progression-free survival were 57 months [95% confidence interval (CI) 47-68] and 26 months (95% CI 20-32) respectively. Younger age and higher CD34+ cell dose infused were independently predictive of improved overall and progression-free survival. Busulphan and cyclophosphamide is an effective and well-tolerated preparative regimen for ASCT that can be given to MM patients in the outpatient setting.
- Subjects :
- Adult
Aged
Antineoplastic Combined Chemotherapy Protocols adverse effects
Busulfan administration & dosage
Busulfan adverse effects
Cyclophosphamide administration & dosage
Cyclophosphamide adverse effects
Epidemiologic Methods
Female
Graft Survival
Hematopoietic Stem Cell Mobilization methods
Humans
Male
Middle Aged
Multiple Myeloma drug therapy
Prognosis
Treatment Outcome
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Hematopoietic Stem Cell Transplantation methods
Multiple Myeloma therapy
Transplantation Conditioning methods
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1048
- Volume :
- 124
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 15009065
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2004.04837.x