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Synthesis and in vitro antimycobacterial activity of novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2004 Mar 22; Vol. 14 (6), pp. 1537-41. - Publication Year :
- 2004
-
Abstract
- Pursuing our search program for new antitubercular drugs we decided to explore the potentiality of oxazolidinone moiety by synthesizing novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480. The new derivatives were tested against atypical mycobacteria as well as against drug resistant Mycobacterium tuberculosis and some of them exhibited a fairly good activity against Mycobacterium avium complex (MAC).
- Subjects :
- Anti-Bacterial Agents pharmacology
Cell Line
Humans
Mycobacterium avium growth & development
Mycobacterium tuberculosis growth & development
Oxazolidinones pharmacology
Anti-Bacterial Agents chemical synthesis
Mycobacterium avium drug effects
Mycobacterium tuberculosis drug effects
Oxazolidinones chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 14
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 15006398
- Full Text :
- https://doi.org/10.1016/j.bmcl.2004.01.010