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The discovery of biaryl acids and amides exhibiting antibacterial activity against Gram-positive bacteria.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2004 Mar 22; Vol. 14 (6), pp. 1423-6. - Publication Year :
- 2004
-
Abstract
- Solid-phase synthetic methods for biaryl-based compounds were developed resulting in the construction of two 1000-member libraries. Numerous compounds were identified by high-throughput screening using whole cell screens to exhibit anti-microbial activity against Gram-positive bacteria. A series of biaryl compounds containing natural and unnatural amino acids were made to explore the SAR of the amino acid functionality.
- Subjects :
- Amides chemistry
Amino Acids chemistry
Anti-Bacterial Agents chemistry
Escherichia coli growth & development
Gram-Positive Bacteria drug effects
Gram-Positive Bacteria growth & development
Microbial Sensitivity Tests statistics & numerical data
Staphylococcus aureus growth & development
Amides pharmacology
Amino Acids pharmacology
Anti-Bacterial Agents pharmacology
Escherichia coli drug effects
Staphylococcus aureus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 14
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 15006375
- Full Text :
- https://doi.org/10.1016/j.bmcl.2004.01.026