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Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2004 Mar 22; Vol. 14 (6), pp. 1417-21. - Publication Year :
- 2004
-
Abstract
- A class of flavanoids exhibiting a high degree of selectivity for ERalpha over ERbeta has been discovered. The most active analogue 6 was found to be 66-fold ERalpha-selective and demonstrated uterine estradiol antagonism.
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 14
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 15006374
- Full Text :
- https://doi.org/10.1016/j.bmcl.2004.01.031