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CC chemokine receptor 5delta32 polymorphism-a risk factor for ischemic-type biliary lesions following orthotopic liver transplantation.
- Source :
-
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society [Liver Transpl] 2004 Mar; Vol. 10 (3), pp. 434-9. - Publication Year :
- 2004
-
Abstract
- Ischemic-type biliary lesions are a major complication following orthotopic liver transplantation. They occur in up to 26% of liver transplant recipients. Among other factors, unknown immunologic factors have always been assumed to be partly responsible for these lesions. CC-chemokines and their receptors play a key role in postoperative immunomodulation after liver transplantation. The non-function CC-chemokine receptor 5delta32 polymorphism (CCR5delta32) has been shown to lead to a lower rate of acute rejection after kidney transplantation; in liver transplantation the role of CCR5delta32 is unclear. We investigated the influence of the CCR5delta32 after liver transplantation with special regard to ischemic-type biliary lesions. The CC-chemokine receptor-5 (CCR5) of 146 recipients was analyzed by polymerase chain reaction to detect CCR5delta32 in blood samples of patients after liver transplantation. One hundred twenty patients with wild-type CCR5 and 26 patients with CCR5delta32 (1 homozygote, 25 heterozygote) were identified. Ischemic-type biliary lesions occurred in 14 of 120 patients with wild-type CCR5 and in 8 of 26 patients with CCR5delta32 polymorphism (P = = 0.01). 5 year patient survival with CCR5delta32 and CCR5 was 70% and 85%, respectively (P =.0067). Our results show that the CCR5delta32 is a significant risk factor for the development of ischemic-type biliary lesions after liver transplantation and leads to a reduction in 5-year survival. In conclusion, the CCR5 status should be screened prospectively before liver transplantation.
- Subjects :
- Adult
Bile Ducts, Intrahepatic immunology
Biliary Tract Diseases immunology
Humans
Ischemia genetics
Liver Transplantation immunology
Middle Aged
Polymorphism, Genetic
Receptors, CCR5 blood
Receptors, CCR5 immunology
Retrospective Studies
Risk Factors
Treatment Outcome
Bile Ducts, Intrahepatic blood supply
Biliary Tract Diseases genetics
Ischemia immunology
Liver Transplantation adverse effects
Receptors, CCR5 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1527-6465
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
- Publication Type :
- Academic Journal
- Accession number :
- 15004773
- Full Text :
- https://doi.org/10.1002/lt.20095