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Lipid profiles in HIV-infected patients receiving combination antiretroviral therapy: are different antiretroviral drugs associated with different lipid profiles?
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2004 Mar 15; Vol. 189 (6), pp. 1056-74. Date of Electronic Publication: 2004 Mar 02. - Publication Year :
- 2004
-
Abstract
- Levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c), as well as the TC:HDL-c ratio, were compared in patients receiving different antiretroviral therapy regimens. Patients receiving first-line regimens including protease inhibitors (PIs) had higher TC and TG levels and TC : HDL-c ratios than did antiretroviral-naive patients; patients receiving 2 PIs had higher levels of each lipid. Ritonavir-containing regimens were associated with higher TC and TG levels and TC : HDL-c ratios than were indinavir-containing regimens; however, receipt of nelfinavir was associated with reduced risk of lower HDL-c levels, and receipt of saquinavir was associated with lower TC : HDL-c ratios. Patients receiving nonnucleoside reverse-transcriptase inhibitors had higher levels of TC and LDL-c than did antiretroviral-naive patients, although the risk of having lower HDL-c levels was lower than that in patients receiving a single PI. Efavirenz was associated with higher levels of TC and TG than was nevirapine.
- Subjects :
- Adult
Anti-HIV Agents administration & dosage
Cholesterol blood
Coronary Disease etiology
Cross-Sectional Studies
Drug Therapy, Combination
Female
HIV Infections blood
Humans
Indinavir adverse effects
Logistic Models
Male
Prospective Studies
Ritonavir adverse effects
Saquinavir adverse effects
Triglycerides blood
Anti-HIV Agents adverse effects
HIV Infections drug therapy
Lipids blood
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 189
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 14999610
- Full Text :
- https://doi.org/10.1086/381783