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Oleanane triterpenoids with inhibitory activity against NFAT transcription factor from Liquidambar formosana.
- Source :
-
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2004 Mar; Vol. 27 (3), pp. 426-8. - Publication Year :
- 2004
-
Abstract
- In a search for inhibitory components from natural products against NFAT transcription factor, this study investigated the ethyl acetate extract of the fruits of Liquidambar formosana. Four oleanane triterpenoids were isolated and identified to be liquidambaric acid, oleanolic acid, 3alpha-acetoxy-25-hydroxy-olean-12-en-28-oic acid and lantanolic acid. Of these compounds, 3alpha-acetoxy-25-hydroxy-olean-12-en-28-oic acid (IC50: 4.63 microM) and lantanolic acid (IC50: 12.62 microM) exhibited strong inhibitory activity against the NFAT transcription factor.
- Subjects :
- Fruit chemistry
Humans
Jurkat Cells
NFATC Transcription Factors
Oleanolic Acid chemistry
Plant Extracts chemistry
Plant Extracts pharmacology
Structure-Activity Relationship
Triterpenes chemistry
DNA-Binding Proteins antagonists & inhibitors
Liquidambar chemistry
Nuclear Proteins antagonists & inhibitors
Oleanolic Acid analogs & derivatives
Oleanolic Acid pharmacology
Transcription Factors antagonists & inhibitors
Triterpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0918-6158
- Volume :
- 27
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biological & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 14993816
- Full Text :
- https://doi.org/10.1248/bpb.27.426