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[Reduction in the aggressiveness of ventilation by inhalation of perfluorohexane after therapy of oleic acid-induced respiratory failure].
- Source :
-
Der Anaesthesist [Anaesthesist] 2004 Feb; Vol. 53 (2), pp. 137-43. - Publication Year :
- 2004
-
Abstract
- Introduction: The application of perfluorohexane (PFH) vapor led to an improvement of oxygenation and mechanical lung function in a model of oleic acid-induced ARDS in sheep. The aim of this study was to investigate the effects of PFH on gas exchange over an extended time period and to reduce the invasiveness of ventilation.<br />Method: ARDS was induced in sheep ( n=12) by injecting 0.1 ml/kg body weight oleic acid intravenously. Six sheep were treated for 30 min with 18 vol.% PFH (PFH-Tx) and followed up over a time period of 240 min while untreated sheep ( n=6) served as controls. Subsequently the F(I)O(2) was reduced to generate a p(a)O(2) between 100-140 mmHg. Gas exchange, respiratory and hemodynamic data were collected at regular intervals. Data were analysed using covariance analysis.<br />Results: PFH treatment led to an improvement in oxygenation ( p<0.01) and in mechanical lung function ( p<0.01). Furthermore, mean pulmonary artery pressure ( p<0.01) and shunt ( p<0.01) were lower in PFH-Tx. F(I)O(2) could be reduced in all PFH-treated animals ( p<0.01).<br />Conclusion: Treatment of oleic acid-induced lung injury with PFH vapor improved oxygenation and mechanical lung function over a extended time period allowing a reduction in the invasiveness of ventilation.
- Subjects :
- Animals
Fluorocarbons administration & dosage
Hemodynamics
Pulmonary Circulation physiology
Pulmonary Gas Exchange
Respiratory Distress Syndrome physiopathology
Respiratory Mechanics drug effects
Respiratory Mechanics physiology
Sheep
Fluorocarbons therapeutic use
Oleic Acid
Respiration, Artificial
Respiratory Distress Syndrome chemically induced
Respiratory Distress Syndrome therapy
Subjects
Details
- Language :
- German
- ISSN :
- 0003-2417
- Volume :
- 53
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Der Anaesthesist
- Publication Type :
- Academic Journal
- Accession number :
- 14991190
- Full Text :
- https://doi.org/10.1007/s00101-003-0622-8