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Increased circulating and intrahepatic T-cell-specific chemokines in chronic hepatitis C: relationship with the type of virological response to peginterferon plus ribavirin combination therapy.
- Source :
-
Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2004 Mar 01; Vol. 19 (5), pp. 551-62. - Publication Year :
- 2004
-
Abstract
- Aims: To determine the serum and intrahepatic levels of T-helper-1-associated chemokines in patients with chronic hepatitis C before, during and after peginterferon plus ribavirin combination therapy and to search for correlations with baseline characteristics of hepatitis C virus-related chronic liver disease and type of therapeutic response.<br />Methods: Serum chemokine levels were determined by enzyme-linked immunosorbent assays and intrahepatic chemokine messenger RNA and protein levels were tested by ribonuclease protection assay and immunohistochemistry.<br />Results: Serum and intrahepatic chemokine levels were elevated in all patients with chronic hepatitis C and showed a marked decrease in patients who obtained a virological response vs. non-responders. Increased serum interferon-gamma-inducible protein-10 levels at baseline in genotype 1-infected patients were significantly associated with greater degrees of intrahepatic inflammation and fibrosis (P = 0.0046 and P = 0.02, respectively) and with virological non-response (P = 0.01). In patients with genotype 1, basal serum interferon-gamma-inducible protein-10 levels greater than 299 pg/mL identified 80% of non-responders and lower than 299 pg/mL identified 63% of responders.<br />Conclusions: Circulating and intrahepatic T-helper-1-associated chemokines are abnormally elevated in patients with chronic hepatitis C. Increased baseline serum interferon-gamma-inducible protein-10 levels in genotype 1-infected patients are associated with virological non-response to peginterferon plus ribavirin combination therapy.
- Subjects :
- Adult
Drug Therapy, Combination
Female
Hepatitis C, Chronic metabolism
Humans
Immunohistochemistry
Interferon alpha-2
Male
Recombinant Proteins
Viral Load
Antiviral Agents therapeutic use
Cytokines metabolism
Hepatitis C, Chronic drug therapy
Interferon-alpha
Polyethylene Glycols
Ribavirin therapeutic use
T-Lymphocytes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0269-2813
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Alimentary pharmacology & therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 14987324
- Full Text :
- https://doi.org/10.1111/j.1365-2036.2004.01872.x