Gene mutation of thiopurine S-methyltransferase in Uygur Chinese.

Authors :: Zhang JP
Guan YY
Xu AL
Zhou SF
Wu JH
Wei H
Huang M
Source :: European journal of clinical pharmacology [Eur J Clin Pharmacol] 2004 Mar; Vol. 60 (1), pp. 1-3. Date of Electronic Publication: 2004 Feb 20.
Publication Year :: 2004
Abstract: Objective: This study was to investigate the gene mutation of thiopurine S-methyltransferase (TPMT) in Uygur Chinese.<br />Methods: Polymerase chain reaction-based methods were used to analyze three commonly reported inactivating mutations-G238C, G460A and A719G.<br />Results: One TPMT*3A heterozygote and five TPMT*3C heterozygotes were found in 160 Uygur Chinese subjects, and allele frequencies of TPMT*3A and TPMT*3C were 0.3% and 1.6%, respectively.<br />Conclusion: TPMT*3C is a common mutant allele in Uygur Chinese, while TPMT*3A is a rare mutant allele in Uygur Chinese.