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Deletion of chromosome band 13q14 as detected by fluorescence in situ hybridization is a prognostic factor in patients with multiple myeloma who are receiving allogeneic dose-reduced stem cell transplantation.

Authors :
Kröger N
Schilling G
Einsele H
Liebisch P
Shimoni A
Nagler A
Perez-Simon JA
San Miguel JF
Kiehl M
Fauser A
Schwerdtfeger R
Wandt H
Sayer HG
Myint H
Klingemann H
Zabelina T
Dierlamm J
Hinke A
Zander AR
Source :
Blood [Blood] 2004 Jun 01; Vol. 103 (11), pp. 4056-61. Date of Electronic Publication: 2004 Feb 24.
Publication Year :
2004

Abstract

We investigated in a retrospective multicenter study the impact of chromosome arm 13q deletion (13q-) as detected by fluorescence in situ hybridization (FISH) on outcome after dose-reduced allografting in patients with multiple myeloma. In 68 of 140 patients, data on chromosome 13q status were available. Most patients included had advanced myeloma. At 2 years, patients with 13q deletion (n = 31) had a shorter event-free (18% vs 42%; P =.05) and overall survival (18% vs 67%; P =.03) than patients without 13q- (n = 37). Patients with 13q- experienced a higher relapse rate (77% vs 44%; P <.001) but a similar incidence of transplantation-related mortality at one year (24% vs 18%). In a multivariate analysis, 13q- remained a significant risk factor for a higher relapse rate (hazard ratio [HR], 3.28; 95% confidence interval [CI], 1.31-8.24; P =.01) and a shorter event-free survival (HR, 1.94; 95% CI, 1.03-3.67; P =.04). Concerning overall survival, 2 or more cycles of prior high-dose chemotherapy were associated with a significantly higher probability of death (HR, 2.48; 95% CI, 1.19-5.17; P =.02), while patients with deletion 13q had a nearly 2 times higher risk of death (HR, 1.94; 95% CI, 0.95-3.98; P =.07) after dose-reduced allogeneic stem cell transplantation.

Details

Language :
English
ISSN :
0006-4971
Volume :
103
Issue :
11
Database :
MEDLINE
Journal :
Blood
Publication Type :
Academic Journal
Accession number :
14982868
Full Text :
https://doi.org/10.1182/blood-2003-12-4435