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Deletion of chromosome band 13q14 as detected by fluorescence in situ hybridization is a prognostic factor in patients with multiple myeloma who are receiving allogeneic dose-reduced stem cell transplantation.
- Source :
-
Blood [Blood] 2004 Jun 01; Vol. 103 (11), pp. 4056-61. Date of Electronic Publication: 2004 Feb 24. - Publication Year :
- 2004
-
Abstract
- We investigated in a retrospective multicenter study the impact of chromosome arm 13q deletion (13q-) as detected by fluorescence in situ hybridization (FISH) on outcome after dose-reduced allografting in patients with multiple myeloma. In 68 of 140 patients, data on chromosome 13q status were available. Most patients included had advanced myeloma. At 2 years, patients with 13q deletion (n = 31) had a shorter event-free (18% vs 42%; P =.05) and overall survival (18% vs 67%; P =.03) than patients without 13q- (n = 37). Patients with 13q- experienced a higher relapse rate (77% vs 44%; P <.001) but a similar incidence of transplantation-related mortality at one year (24% vs 18%). In a multivariate analysis, 13q- remained a significant risk factor for a higher relapse rate (hazard ratio [HR], 3.28; 95% confidence interval [CI], 1.31-8.24; P =.01) and a shorter event-free survival (HR, 1.94; 95% CI, 1.03-3.67; P =.04). Concerning overall survival, 2 or more cycles of prior high-dose chemotherapy were associated with a significantly higher probability of death (HR, 2.48; 95% CI, 1.19-5.17; P =.02), while patients with deletion 13q had a nearly 2 times higher risk of death (HR, 1.94; 95% CI, 0.95-3.98; P =.07) after dose-reduced allogeneic stem cell transplantation.
- Subjects :
- Adult
Aged
Disease-Free Survival
Female
Graft vs Host Disease mortality
Humans
In Situ Hybridization, Fluorescence
Male
Middle Aged
Multiple Myeloma mortality
Predictive Value of Tests
Prognosis
Recurrence
Remission Induction
Risk Factors
Survival Analysis
Transplantation Chimera
Chromosome Deletion
Chromosomes, Human, Pair 13
Hematopoietic Stem Cell Transplantation
Multiple Myeloma genetics
Multiple Myeloma therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0006-4971
- Volume :
- 103
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 14982868
- Full Text :
- https://doi.org/10.1182/blood-2003-12-4435