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Cis association of Ly49A with MHC class I restricts natural killer cell inhibition.
- Source :
-
Nature immunology [Nat Immunol] 2004 Mar; Vol. 5 (3), pp. 328-36. Date of Electronic Publication: 2004 Feb 15. - Publication Year :
- 2004
-
Abstract
- Natural killer (NK) cell function is negatively regulated by inhibitory receptors interacting with major histocompatibility complex class I molecules expressed on target cells. Here we show that the inhibitory Ly49A NK cell receptor not only binds to its H-2D(d) ligand expressed on potential target cells (in trans) but also is constitutively associated with H-2D(d) in cis (on the same cell). Cis association and trans interaction occur through the same binding site. Consequently, cis association restricts the number of Ly49A receptors available for binding of H-2D(d) on target cells and reduces NK cell inhibition through Ly49A. By lowering the threshold at which NK cell activation exceeds NK cell inhibition, cis interaction allows optimal discrimination of normal and abnormal host cells.
- Subjects :
- Animals
Antigens, Ly genetics
Antigens, Ly metabolism
Binding Sites
Cell Line
Cell Line, Tumor
Cytotoxicity Tests, Immunologic
H-2 Antigens metabolism
Histocompatibility Antigen H-2D
Lectins, C-Type
Mice
Mice, Inbred C57BL
Mice, Transgenic
Models, Immunological
Mosaicism
NK Cell Lectin-Like Receptor Subfamily A
Neoplasms immunology
Receptors, Immunologic metabolism
Receptors, NK Cell Lectin-Like
Transfection
Antigens, Ly physiology
Cytotoxicity, Immunologic
Histocompatibility Antigens Class I metabolism
Killer Cells, Natural immunology
Receptors, Immunologic physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2908
- Volume :
- 5
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14973437
- Full Text :
- https://doi.org/10.1038/ni1043