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Investigations into a new antiarrhythmic substance Z-2-amino-5-chlor-benzophenon-amidin-hydralazin in humans.
- Source :
-
International journal of clinical pharmacology, therapy, and toxicology [Int J Clin Pharmacol Ther Toxicol] 1992 Nov; Vol. 30 (11), pp. 513-4. - Publication Year :
- 1992
-
Abstract
- Z-2-amino-5-chlor-benzophenon-amidin-hydralazin is a new chemical potential antiarrhythmic substance. The blood levels were investigated after different dosages and forms of administration in patients and volunteers. The determination of the substance can be performed by high-pressure liquid chromatography. In addition the pharmacokinetic parameters were calculated. The pharmacokinetic profile is similar in humans and animals.
- Subjects :
- Administration, Oral
Anti-Arrhythmia Agents therapeutic use
Humans
Hydralazine pharmacokinetics
Hydralazine therapeutic use
Injections, Intravenous
Intestinal Absorption
Male
Tachycardia drug therapy
Anti-Arrhythmia Agents pharmacokinetics
Hydralazine analogs & derivatives
Tachycardia metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0174-4879
- Volume :
- 30
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- International journal of clinical pharmacology, therapy, and toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 1490815