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Effect of pravastatin, a potent 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on survival of AH130 hepatoma-bearing rats.
- Source :
-
Japanese journal of cancer research : Gann [Jpn J Cancer Res] 1992 Nov; Vol. 83 (11), pp. 1120-3. - Publication Year :
- 1992
-
Abstract
- 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor is known to have an inhibitory effect on cell growth in addition to a cholesterol-lowering effect. This study examined the effect of pravastatin, a potent inhibitor of HMG-CoA reductase, on the survival of AH130 hepatoma-bearing rats. Pravastatin (1, 2, or 8 mg/kg body weight) was intraperitoneally injected once a day into tumor-bearing rats. The difference in the survival curves was significant between the controls and the rats treated with 8 mg/kg of pravastatin (P < 0.019 by logrank test) but not between the controls and the rats treated with 1 or 2 mg/kg of the inhibitor. The tumor volume was significantly decreased in the rats treated with 8 mg/kg of pravastatin (P < 0.05). These observations showed that intraperitoneal injection of pravastatin could improve the survival of AH130 hepatoma-bearing rats and had an inhibitory effect on the growth of the ascites form tumor.
- Subjects :
- Animals
Cholesterol blood
Dose-Response Relationship, Drug
Injections, Intraperitoneal
Liver Neoplasms, Experimental enzymology
Male
Neoplasm Transplantation
Rats
Rats, Inbred Strains
Antineoplastic Agents pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Liver Neoplasms, Experimental drug therapy
Pravastatin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0910-5050
- Volume :
- 83
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Japanese journal of cancer research : Gann
- Publication Type :
- Academic Journal
- Accession number :
- 1483925
- Full Text :
- https://doi.org/10.1111/j.1349-7006.1992.tb02732.x