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Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 1992 Dec 25; Vol. 35 (26), pp. 4914-7. - Publication Year :
- 1992
- Subjects :
- Amino Acid Sequence
Fibrinogen metabolism
Molecular Sequence Data
Oligopeptides chemical synthesis
Platelet Aggregation Inhibitors chemical synthesis
Receptors, Immunologic drug effects
Receptors, Immunologic metabolism
Structure-Activity Relationship
Fibrinogen pharmacology
Oligopeptides pharmacology
Platelet Aggregation drug effects
Platelet Aggregation Inhibitors pharmacology
Platelet Glycoprotein GPIb-IX Complex
Platelet Membrane Glycoproteins
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2623
- Volume :
- 35
- Issue :
- 26
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 1479591
- Full Text :
- https://doi.org/10.1021/jm00104a019