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Lipid core peptide technology and group A streptococcal vaccine delivery.
- Source :
-
Expert review of vaccines [Expert Rev Vaccines] 2004 Feb; Vol. 3 (1), pp. 43-58. - Publication Year :
- 2004
-
Abstract
- The antiphagocytic surface M protein of group A streptococcus has been widely studied as the major candidate antigen for a vaccine to prevent group A streptococcus infection. Approaches that have proven to be effective in animal models include the use of multi-epitope vaccines incorporating highly variable amino terminal serotypic determinants, those based on the carboxy terminal conserved region and combination vaccines incorporating both serotypic and conserved region determinants of the M protein. The use of lipid core peptide technology is at the forefront of this research in the quest to develop a broad-strain protective vaccine that can be delivered via the mucosal route, stimulating mucosal and systemic immunity. This review aims to cover the various strategies and technologies that have been investigated with regard to group A streptococcus vaccine design and development.
- Subjects :
- Animals
Antigens, Bacterial chemistry
Autoimmune Diseases immunology
Autoimmune Diseases prevention & control
Bacterial Outer Membrane Proteins chemistry
Carrier Proteins chemistry
Humans
Immunity, Mucosal
Lipids chemistry
Streptococcal Infections epidemiology
Streptococcal Infections immunology
Streptococcal Infections prevention & control
Streptococcal Vaccines immunology
Vaccines, Subunit administration & dosage
Vaccines, Subunit immunology
Vaccines, Synthetic administration & dosage
Vaccines, Synthetic immunology
Antigens, Bacterial immunology
Bacterial Outer Membrane Proteins immunology
Carrier Proteins immunology
Drug Delivery Systems methods
Lipids immunology
Streptococcal Vaccines administration & dosage
Streptococcus pyogenes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-0584
- Volume :
- 3
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Expert review of vaccines
- Publication Type :
- Academic Journal
- Accession number :
- 14761243
- Full Text :
- https://doi.org/10.1586/14760584.3.1.43