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The combination of enoxaparin, glycoprotein IIb/IIIa inhibitors and an early invasive approach among acute coronary syndrome patients.
- Source :
-
The Journal of invasive cardiology [J Invasive Cardiol] 2004 Feb; Vol. 16 (2), pp. 46-51. - Publication Year :
- 2004
-
Abstract
- Objectives: This study was designed to assess the feasibility and safety of enoxaparin in combination with glycoprotein (GP) IIb/IIIa inhibitors during percutaneous coronary intervention (PCI) as part of an early invasive strategy in patients presenting with acute coronary syndromes (ACS).<br />Background: Trials in patients with ACS have evaluated the utility of enoxaparin, adjuvant GP IIb/IIIa inhibitors with PCI, and an early invasive approach. Information about the combination of all three of these approaches, however, is limited.<br />Methods: Forty-nine patients with ACS underwent cardiac catheterization, of whom 23 underwent PCI with enoxaparin and GP IIb/IIIa inhibitors.<br />Results: The primary endpoint of the study, a composite of death, myocardial infarction or urgent revascularization at 30 days, occurred in 8% of patients undergoing PCI. There were no deaths. One patient received a blood transfusion. No other adverse events occurred. These event rates were comparable to those from the pooled EPILOG/EPISTENT database, in which intravenous unfractionated heparin was used in conjunction with GP IIb/IIIa receptor blockade. The mean anti-Xa level in patients undergoing PCI was 0.74 0.48 U/ml. The majority of patients who underwent PCI within eight hours of their last dose of enoxaparin had therapeutic anti-Xa levels.<br />Conclusion: In patients with ACS, enoxaparin in combination with GP IIb/IIIa inhibitors and an early invasive approach resulted in comparable clinical complication and bleeding rates versus historical references utilizing unfractionated heparin.
- Subjects :
- Acute Disease
Anticoagulants adverse effects
Coronary Disease epidemiology
Drug Therapy, Combination
Enoxaparin adverse effects
Factor Xa drug effects
Factor Xa metabolism
Female
Humans
Male
Middle Aged
Ohio
Pilot Projects
Platelet Aggregation Inhibitors adverse effects
Platelet Glycoprotein GPIIb-IIIa Complex adverse effects
Prospective Studies
Syndrome
Time Factors
Treatment Outcome
Angioplasty, Balloon, Coronary
Anticoagulants therapeutic use
Coronary Disease therapy
Enoxaparin therapeutic use
Platelet Aggregation Inhibitors therapeutic use
Platelet Glycoprotein GPIIb-IIIa Complex antagonists & inhibitors
Platelet Glycoprotein GPIIb-IIIa Complex therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1042-3931
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of invasive cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 14760188