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Measuring mucosal damage induced by cytotoxic therapy.
- Source :
-
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2004 Apr; Vol. 12 (4), pp. 227-33. Date of Electronic Publication: 2004 Jan 30. - Publication Year :
- 2004
-
Abstract
- We scored oral mucositis and gut toxicity and measured sugar permeability testing among 56 recipients of a haematopoietic stem cell transplant (HSCT) given myeloablative conditioning with idarubicin, cyclophosphamide and TBI, and a group of 18 patients given cytotoxic chemotherapy for newly diagnosed acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS). Gut integrity was already disturbed in the AML/MDS group as measured by the lactulose/rhamnose ratio (L/R ratio=0.09) before therapy and was severely perturbed (L/R ratio >0.13) for a month after HSCT. Oral mucositis and to a lesser extent gut toxicity was only significantly correlated with disturbed permeability in the transplant group. The data suggest that sugar permeability, oral mucositis and gut toxicity measure different features of mucosal damage after intensive cytotoxic therapy.
- Subjects :
- 3-O-Methylglucose pharmacokinetics
Acute Disease
Adult
Antibiotics, Antineoplastic adverse effects
Antineoplastic Agents, Alkylating adverse effects
Cyclophosphamide adverse effects
Female
Gastric Mucosa radiation effects
Hematopoietic Stem Cell Transplantation
Humans
Idarubicin adverse effects
Intestinal Mucosa radiation effects
Lactulose pharmacokinetics
Leukemia, Myeloid therapy
Male
Middle Aged
Mouth Mucosa radiation effects
Myelodysplastic Syndromes therapy
Permeability
Rhamnose pharmacokinetics
Stomatitis chemically induced
Stomatitis etiology
Whole-Body Irradiation
Xylose pharmacokinetics
Antineoplastic Agents adverse effects
Gastric Mucosa drug effects
Intestinal Mucosa drug effects
Mouth Mucosa drug effects
Transplantation Conditioning adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0941-4355
- Volume :
- 12
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 14752625
- Full Text :
- https://doi.org/10.1007/s00520-003-0572-3