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An overview of the clinical pharmacokinetics of nabumetone.
- Source :
-
The Journal of rheumatology. Supplement [J Rheumatol Suppl] 1992 Nov; Vol. 36, pp. 20-4. - Publication Year :
- 1992
-
Abstract
- Nabumetone is a new, nonacidic, nonsteroidal antiinflammatory drug. At least 80% of nabumetone is absorbed, and food, milk, and aluminum antacids increase the rate, but not the extent, of absorption. It is rapidly metabolized in the liver to 6-methoxy-2-naphthylacetic acid (6MNA), the major circulating active metabolite. At steady state, the time to maximum plasma concentration for 6MNA is 1 to 4 h. 6MNA has a very low clearance rate and long half-life (about 24 h). In general, steady state plasma concentrations of 6MNA increase in proportion with increases in the dose of nabumetone administered. Steady state plasma concentrations of 6MNA in the elderly are slightly higher than in healthy volunteers; however, this does not appear to be clinically significant. Preliminary studies in patients with impaired renal function indicate that the pharmacokinetics are not altered in patients with mild to moderate disease.
- Subjects :
- Adult
Aged
Aging metabolism
Antacids pharmacology
Anti-Inflammatory Agents, Non-Steroidal metabolism
Anti-Inflammatory Agents, Non-Steroidal pharmacokinetics
Anti-Inflammatory Agents, Non-Steroidal urine
Butanones metabolism
Butanones urine
Eating
Humans
Kidney Diseases metabolism
Liver Diseases metabolism
Nabumetone
Butanones pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0380-0903
- Volume :
- 36
- Database :
- MEDLINE
- Journal :
- The Journal of rheumatology. Supplement
- Publication Type :
- Academic Journal
- Accession number :
- 1474531