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Potential application of tissue Doppler imaging to assess regional left ventricular diastolic function in patients with hypertrophic cardiomyopathy: comparison with 123I-beta-methyl iodophenyl pentadecanoic acid myocardial scintigraphy.
- Source :
-
Clinical cardiology [Clin Cardiol] 2004 Jan; Vol. 27 (1), pp. 33-9. - Publication Year :
- 2004
-
Abstract
- Background: Tissue Doppler imaging (TDI) has been utilized to evaluate left ventricular myocardial dysfunction in patients with hypertrophic cardiomyopathy (HCM); however, no clear explanation for the abnormality of TDI variables has been forthcoming.<br />Hypothesis: Peak negative myocardial velocity gradient (MVG) derived from TDI may correlate with a disorder of fatty acid metabolism in patients with HCM.<br />Methods: Tissue Doppler imaging and 123I-beta-methyl iodophenyl pentadecanoic acid (123I-BMIPP) myocardial scintigraphy were performed in 15 patients with asymmetric septal hypertrophy (mean age 47 +/- 18 years) and in 12 healthy controls (mean age 43 +/- 10 years).<br />Results: In early 123I-BMIPP images, accumulation defects were observed in the ventricular septum in 12 patients and in the posterior wall in 8 patients with HCM. Peak negative MVG in the ventricular septum (1.1 +/- 0.5 vs. 2.8 +/- 0.5, p < 0.0001) and posterior wall (5.2 +/- 1.4 vs. 6.7 +/- 0.8, p < 0.01 ) was significantly lower in the HCM group than in the controls; also, these parameters were significantly lower in patients with than in those without a defect in the region in question. The peak negative MVG in the ventricular septum and posterior wall correlated inversely with the washout rate in all subjects.<br />Conclusions: Peak negative MVG according to TDI is related to disorder of fatty acid metabolism in the regional left ventricular myocardium of patients with HCM.
- Subjects :
- Cardiomyopathy, Hypertrophic metabolism
Case-Control Studies
Diastole
Echocardiography, Doppler, Pulsed
Female
Heart Septum diagnostic imaging
Heart Septum metabolism
Humans
Male
Middle Aged
Myocardium metabolism
Radionuclide Imaging
Ventricular Dysfunction, Left metabolism
Cardiomyopathy, Hypertrophic diagnostic imaging
Fatty Acids metabolism
Iodine Radioisotopes
Iodobenzenes
Ventricular Dysfunction, Left diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 0160-9289
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 14743854
- Full Text :
- https://doi.org/10.1002/clc.4960270109