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Validation of QGS and 4D-MSPECT for quantification of left ventricular volumes and ejection fraction from gated 18F-FDG PET: comparison with cardiac MRI.
- Source :
-
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2004 Jan; Vol. 45 (1), pp. 74-9. - Publication Year :
- 2004
-
Abstract
- Unlabelled: The aim of this study was to validate Quantitative Gated SPECT (QGS) and 4D-MSPECT for assessing left ventricular end-diastolic and systolic volumes (EDV and ESV, respectively) and left ventricular ejection fraction (LVEF) from gated (18)F-FDG PET.<br />Methods: Forty-four patients with severe coronary artery disease were examined with gated (18)F-FDG PET (8 gates per cardiac cycle). EDV, ESV, and LVEF were calculated from gated (18)F-FDG PET using QGS and 4D-MSPECT. Within 2 d (median), cardiovascular cine MRI (cMRI) (20 gates per cardiac cycle) was done as a reference.<br />Results: QGS failed to accurately detect myocardial borders in 1 patient; 4D-MSPECT, in 2 patients. For the remaining 42 patients, correlation between the results of gated (18)F-FDG PET and cMRI was high for EDV (R = 0.94 for QGS and 0.94 for 4D-MSPECT), ESV (R = 0.95 for QGS and 0.95 for 4D-MSPECT), and LVEF (R = 0.94 for QGS and 0.90 for 4D-MSPECT). QGS significantly (P < 0.0001) underestimated LVEF, whereas no other parameter differed significantly between gated (18)F-FDG PET and cMRI for either algorithm.<br />Conclusion: Despite small systematic differences that, among other aspects, limit interchangeability, agreement between gated (18)F-FDG PET and cMRI is good across a wide range of clinically relevant volumes and LVEF values assessed by QGS and 4D-MSPECT.
- Subjects :
- Aged
Aged, 80 and over
Coronary Artery Disease complications
Coronary Artery Disease diagnosis
Female
Humans
Image Interpretation, Computer-Assisted methods
Magnetic Resonance Imaging methods
Male
Middle Aged
Radiopharmaceuticals
Reproducibility of Results
Sensitivity and Specificity
Statistics as Topic
Tomography, Emission-Computed methods
Ventricular Dysfunction, Left diagnosis
Ventricular Dysfunction, Left etiology
Coronary Artery Disease diagnostic imaging
Fluorodeoxyglucose F18
Gated Blood-Pool Imaging methods
Heart Ventricles diagnostic imaging
Stroke Volume
Tomography, Emission-Computed, Single-Photon methods
Ventricular Dysfunction, Left diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 0161-5505
- Volume :
- 45
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 14734676