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Clinical impact and diagnosis of human metapneumovirus infection.
- Source :
-
The Pediatric infectious disease journal [Pediatr Infect Dis J] 2004 Jan; Vol. 23 (1 Suppl), pp. S25-32. - Publication Year :
- 2004
-
Abstract
- Background: Acute respiratory infections are the most common illnesses experienced by people of all ages worldwide. A portion of hitherto unexplained viral respiratory tract illnesses (RTIs) can now be attributed to the human metapneumovirus (hMPV), which was discovered in 2001. Several surveys on the burden of disease of hMPV infection have been conducted in various study groups and with different diagnostic assays. To estimate the impact of hMPV infection in a hospital setting and in the community at large, we reviewed these surveys to establish the burden of disease of hMPV infection.<br />Methods: Published data and our own additional unpublished data on the clinical impact of hMPV infection were reviewed.<br />Results and Conclusion: Worldwide, hMPV infections account for at least 5 to 7% of the RTI in hospitalized children, but immunocompromised and elderly individuals are also at risk. In the general community hMPV infections account for at least 3% of patients who visit a general practitioner for RTI. The seasonality of hMPV infections resembles that for respiratory syncytial virus and influenza virus infections, with recurrent epidemics during the winter months. Clinical symptoms and laboratory findings associated with hMPV infection exhibit a spectrum virtually indistinguishable from those associated with respiratory syncytial virus disease. The development of diagnostic assays must take into account the existence of two hMPV serotypes.
- Subjects :
- Acute Disease
Adolescent
Age Distribution
Aged
Child
Child, Preschool
Female
Hospitalization statistics & numerical data
Humans
Infant
Male
Middle Aged
Netherlands epidemiology
Paramyxoviridae Infections epidemiology
Prognosis
Respiratory Tract Infections epidemiology
Risk Assessment
Severity of Illness Index
Sex Distribution
Metapneumovirus isolation & purification
Paramyxoviridae Infections diagnosis
Respiratory Syncytial Virus Infections diagnosis
Respiratory Syncytial Virus Infections epidemiology
Respiratory Tract Infections virology
Subjects
Details
- Language :
- English
- ISSN :
- 0891-3668
- Volume :
- 23
- Issue :
- 1 Suppl
- Database :
- MEDLINE
- Journal :
- The Pediatric infectious disease journal
- Publication Type :
- Academic Journal
- Accession number :
- 14730267
- Full Text :
- https://doi.org/10.1097/01.inf.0000108190.09824.e8