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Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000.
- Source :
-
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2004 Feb 01; Vol. 38 (3), pp. 311-20. Date of Electronic Publication: 2004 Jan 14. - Publication Year :
- 2004
-
Abstract
- Candida species are among the most common bloodstream pathogens in the United States, where the emergence of azole-resistant Candida glabrata and Candida krusei are major concerns. Recent comprehensive longitudinal data from Europe are lacking. We conducted a nationwide survey of candidemia during 1991-2000 in 17 university and university-affiliated hospitals representing 79% of all tertiary care hospital beds in Switzerland. The number of transplantations and bloodstream infections increased significantly (P<.001). A total of 1137 episodes of candidemia were observed: Candida species ranked seventh among etiologic agents (2.9% of all bloodstream isolates). The incidence of candidemia was stable over a 10-year period. C. albicans remained the predominant Candida species recovered (66%), followed by C. glabrata (15%). Candida tropicalis emerged (9%), the incidence of Candida parapsilosis decreased (1%), and recovery of C. krusei remained rare (2%). Fluconazole consumption increased significantly (P<.001). Despite increasing high-risk activities, the incidence of candidemia remained unchanged, and no shift to resistant species occurred.
- Subjects :
- Antifungal Agents therapeutic use
Candidiasis drug therapy
Cross Infection drug therapy
Cross Infection microbiology
Data Collection
Drug Resistance, Microbial
Fluconazole therapeutic use
Fungemia drug therapy
Hospitals, University
Humans
Longitudinal Studies
Microbial Sensitivity Tests
Switzerland epidemiology
United States epidemiology
Candidiasis epidemiology
Cross Infection epidemiology
Fungemia epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6591
- Volume :
- 38
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Publication Type :
- Academic Journal
- Accession number :
- 14727199
- Full Text :
- https://doi.org/10.1086/380637