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Removal of G(ialpha1) constraints on adenylyl cyclase in the hippocampus enhances LTP and impairs memory formation.
- Source :
-
Neuron [Neuron] 2004 Jan 08; Vol. 41 (1), pp. 153-63. - Publication Year :
- 2004
-
Abstract
- Stimulation of adenylyl cyclase in the hippocampus is critical for memory formation. However, generation of cAMP signals within an optimal range for memory may require a balance between stimulatory and inhibitory mechanisms. The role of adenylyl cyclase inhibitory mechanisms for memory has not been addressed. One of the mechanisms for inhibition of adenylyl cyclase is through activation of G(i)-coupled receptors, a mechanism that could serve as a constraint on memory formation. Here we report that ablation of G(ialpha1) by gene disruption increases hippocampal adenylyl cyclase activity and enhances LTP in area CA1. Furthermore, gene ablation of G(ialpha1) or antisense oligonucleotide-mediated depletion of G(ialpha1) disrupted hippocampus-dependent memory. We conclude that G(ialpha1) provides a critical mechanism for tonic inhibition of adenylyl cyclase activity in the hippocampus. We hypothesize that loss of G(ialpha1) amplifies the responsiveness of CA1 postsynaptic neurons to stimuli that strengthen synaptic efficacy, thereby diminishing synapse-specific plasticity required for new memory formation.
- Subjects :
- Animals
GTP-Binding Protein alpha Subunits, Gi-Go antagonists & inhibitors
GTP-Binding Protein alpha Subunits, Gi-Go genetics
Gene Deletion
Hippocampus physiology
Memory drug effects
Mice
Mice, Inbred C57BL
Pertussis Toxin pharmacology
Adenylyl Cyclases metabolism
GTP-Binding Protein alpha Subunits, Gi-Go physiology
Hippocampus enzymology
Long-Term Potentiation physiology
Memory physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0896-6273
- Volume :
- 41
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 14715142
- Full Text :
- https://doi.org/10.1016/s0896-6273(03)00813-4