Back to Search Start Over

Evolutionary characteristics of HIV type 1 variants resistant to protease inhibitors in the absence of drug-selective pressure.

Authors :
Boeri E
Gianotti N
Canducci F
Hasson H
Giudici B
Castagna A
Lazzarin A
Clementi M
Source :
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2003 Dec; Vol. 19 (12), pp. 1151-3.
Publication Year :
2003

Abstract

To understand the evolutionary characteristics of HIV-1 variants resistant to protease inhibitors (PI), the replicating plasma virus was analyzed in three patients shifted to PI-sparing regimen after virological failure. The dynamic features of carryover mutations associated with PI resistance in the absence of selective pressure on the protease gene indicate that viral variants resistant to reverse transcriptase inhibitors and bearing mutations of the protease sequence can maintain efficient replication capacity in vivo.

Details

Language :
English
ISSN :
0889-2229
Volume :
19
Issue :
12
Database :
MEDLINE
Journal :
AIDS research and human retroviruses
Publication Type :
Academic Journal
Accession number :
14714567
Full Text :
https://doi.org/10.1089/088922203771881257