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Evolutionary characteristics of HIV type 1 variants resistant to protease inhibitors in the absence of drug-selective pressure.
- Source :
-
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2003 Dec; Vol. 19 (12), pp. 1151-3. - Publication Year :
- 2003
-
Abstract
- To understand the evolutionary characteristics of HIV-1 variants resistant to protease inhibitors (PI), the replicating plasma virus was analyzed in three patients shifted to PI-sparing regimen after virological failure. The dynamic features of carryover mutations associated with PI resistance in the absence of selective pressure on the protease gene indicate that viral variants resistant to reverse transcriptase inhibitors and bearing mutations of the protease sequence can maintain efficient replication capacity in vivo.
Details
- Language :
- English
- ISSN :
- 0889-2229
- Volume :
- 19
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- AIDS research and human retroviruses
- Publication Type :
- Academic Journal
- Accession number :
- 14714567
- Full Text :
- https://doi.org/10.1089/088922203771881257