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Ritanserin counteracts both rat vacuous chewing movements and nigro-striatal tyrosine hydroxylase-immunostaining alterations induced by haloperidol.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2004 Jan 01; Vol. 483 (1), pp. 65-9. - Publication Year :
- 2004
-
Abstract
- The effect of subchronic co-administration of ritanserin (1.5 mg/kg, i.p., twice a day) and haloperidol (1 mg/kg, i.p., twice a day) on rat vacuous chewing movements and on tyrosine hydroxylase-immunostaining was investigated. Ritanserin significantly reduced rat vacuous chewing movements observed following 2, 3 and 4 weeks of haloperidol administration and after 5 days of haloperidol withdrawal. Furthermore, ritanserin prevented the reduction of striatal tyrosine hydroxylase-immunostaining and the shrinkage of nigral dopaminergic cell bodies induced by haloperidol. The present results indicate that ritanserin may possess protective properties on both dopaminergic nigro-striatal neuron alterations and vacuous chewing movements induced by haloperidol, and provide further evidence indicating a possible association between these two haloperidol-induced effects.
- Subjects :
- Animals
Cell Size
Immunohistochemistry
Male
Neostriatum drug effects
Rats
Rats, Sprague-Dawley
Substantia Nigra cytology
Substantia Nigra drug effects
Antipsychotic Agents therapeutic use
Antipsychotic Agents toxicity
Dyskinesia, Drug-Induced drug therapy
Haloperidol antagonists & inhibitors
Haloperidol toxicity
Neostriatum enzymology
Ritanserin therapeutic use
Substantia Nigra enzymology
Tyrosine 3-Monooxygenase metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 483
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 14709327
- Full Text :
- https://doi.org/10.1016/j.ejphar.2003.10.005