Back to Search
Start Over
Role of laboratory in the management of phenylbutazone poisoning.
- Source :
-
Journal of toxicology. Clinical toxicology [J Toxicol Clin Toxicol] 2003; Vol. 41 (7), pp. 1013-24. - Publication Year :
- 2003
-
Abstract
- We report a rare case of intentional overdose of phenylbutazone in a 15-yr-old female. The patient exhibited symptoms of phenylbutazone toxicity and the presence of the drug was confirmed by gas chromatography mass-spectrometry (GC-MS) analysis of the initial urine sample. The patient underwent plasmapheresis to remove the drug from the circulation. Semiquantitation of sequential serum samples by GC-MS revealed elimination of phenylbutazone by day 5 of admission at which time the plasmapheresis was discontinued. Elevated blood urea nitrogen (BUN) and creatinine returned to normal. Analysis of biomarkers for liver necrosis and regeneration in sequential serum samples revealed the restoration of normal liver function by day 5. This case further confirms our previous observations that biomarkers for liver necrosis and regeneration can predict the outcome of patients with liver damage due to toxins.
- Subjects :
- Adolescent
Anti-Inflammatory Agents, Non-Steroidal urine
Biomarkers blood
Female
Gas Chromatography-Mass Spectrometry
Humans
Liver physiopathology
Liver Function Tests
Phenylbutazone urine
Poisoning blood
Poisoning physiopathology
Poisoning urine
Anti-Inflammatory Agents, Non-Steroidal poisoning
Laboratories, Hospital
Phenylbutazone poisoning
Poisoning diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0731-3810
- Volume :
- 41
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of toxicology. Clinical toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 14705852
- Full Text :
- https://doi.org/10.1081/clt-120026528