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Decreased human T lymphotropic virus type I (HTLV-I) provirus load and alteration in T cell phenotype after interferon-alpha therapy for HTLV-I-associated myelopathy/tropical spastic paraparesis.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2004 Jan 01; Vol. 189 (1), pp. 29-40. Date of Electronic Publication: 2003 Dec 31. - Publication Year :
- 2004
-
Abstract
- To analyze the mechanism by which interferon (IFN)-alpha is effective against human T cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we investigated the T cell phenotype and HTLV-I provirus load in peripheral blood mononuclear cells from 25 patients with HAM/TSP that were obtained before and after administration of IFN-alpha. The frequency of memory (CD45RA(-)CD27(+)) T cells that were CD8(high+), CXCR3(+) cell populations, and HTLV-I provirus loads were significantly decreased after treatment. The proportion of memory T cells in the CD8(high+) cell population correlated well with HTLV-I provirus load, whereas the proportion of effector (CD45RA(+)CD27(-)) cells in the CD8(high+) cell population was inversely correlated with provirus load. Interestingly, the frequency of perforin expression in CD8(high+) cells was significantly decreased after treatment in patients who experienced clinical improvement, whereas patients who did not experience clinical improvement showed an increased frequency of perforin expression. Our data suggest that fluctuations in these cell subsets are associated with both the immunomodulatory effect of IFN-alpha and the observed clinical benefit of IFN-alpha treatment in patients with HAM/TSP.
- Subjects :
- Adult
Aged
CD8 Antigens analysis
Female
Humans
Immunologic Memory
Injections, Intramuscular
Leukocyte Common Antigens analysis
Lymphocyte Count
Male
Membrane Glycoproteins analysis
Membrane Glycoproteins biosynthesis
Middle Aged
Paraparesis, Tropical Spastic blood
Paraparesis, Tropical Spastic immunology
Perforin
Pore Forming Cytotoxic Proteins
Receptors, CXCR3
Receptors, Chemokine analysis
Treatment Outcome
Tumor Necrosis Factor Receptor Superfamily, Member 7 analysis
Viral Load
Adjuvants, Immunologic therapeutic use
Human T-lymphotropic virus 1 isolation & purification
Interferon-alpha therapeutic use
Paraparesis, Tropical Spastic drug therapy
Proviruses isolation & purification
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 189
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 14702150
- Full Text :
- https://doi.org/10.1086/380101