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In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2004 Jan; Vol. 48 (1), pp. 337-9. - Publication Year :
- 2004
-
Abstract
- The nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 (Dapivirine) effectively prevented human immunodeficiency virus (HIV) infection in cocultures of monocyte-derived dendritic cells and T cells, representing primary targets in sexual transmission. Both drugs had a favorable therapeutic index. A 24-h treatment with 1,000 nM UC-781 or 100 nM TMC120-R147681 prevented cell-free HIV infection, whereas 10-fold-higher concentrations blocked cell-associated HIV.
- Subjects :
- CD4-Positive T-Lymphocytes drug effects
CD4-Positive T-Lymphocytes virology
Cell-Free System
Cells, Cultured
Coculture Techniques
Dendritic Cells virology
Enzyme-Linked Immunosorbent Assay
HIV Infections virology
HIV-1
Humans
Pyrimidines pharmacology
Thioamides
Anilides pharmacology
Anti-HIV Agents pharmacology
Furans pharmacology
HIV Infections prevention & control
Reverse Transcriptase Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 48
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 14693562
- Full Text :
- https://doi.org/10.1128/AAC.48.1.337-339.2004