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Molecular basis for the antiandrogen withdrawal syndrome.

Authors :
Miyamoto H
Rahman MM
Chang C
Source :
Journal of cellular biochemistry [J Cell Biochem] 2004 Jan 01; Vol. 91 (1), pp. 3-12.
Publication Year :
2004

Abstract

In patients with prostate cancer who manifest disease progression during combined androgen blockade therapy, discontinuation of antiandrogen treatment might result in prostate-specific antigen decline, often associated with clinical improvement. The response called antiandrogen withdrawal syndrome is thus acknowledged as a general phenomenon. However, molecular mechanisms responsible for this syndrome are not completely understood. This article outlines the proposed mechanisms, including alterations of androgen receptor gene and its coregulatory proteins and activation of the signal transduction pathway, and the potential therapeutic approaches based on the specific mechanisms.<br /> (Copyright 2003 Wiley-Liss, Inc.)

Details

Language :
English
ISSN :
0730-2312
Volume :
91
Issue :
1
Database :
MEDLINE
Journal :
Journal of cellular biochemistry
Publication Type :
Academic Journal
Accession number :
14689576
Full Text :
https://doi.org/10.1002/jcb.10757