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Does the correlation between EBNA-1 and p63 expression in breast carcinomas provide a clue to tumorigenesis in Epstein-Barr virus-related breast malignancies?
- Source :
-
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 2004 Jan; Vol. 37 (1), pp. 89-95. Date of Electronic Publication: 2003 Dec 18. - Publication Year :
- 2004
-
Abstract
- Several investigators have identified Epstein-Barr virus (EBV) particles in breast carcinomas, a fact that supports a role for EBV in mammary tumorigenesis. The possible mechanism involved in this process is not clear. The present study was carried out in an attempt to determine whether there is a relationship between latent infection with EBV and p53 and p63 expression in breast carcinomas. Immunohistochemistry developed with 3.3-diaminobenzidine tetrahydrochloride was performed in 85 formalin-fixed paraffin-embedded breast carcinomas using anti-EBV EBNA-1, anti-p63, anti-p53, anti-estrogen receptor (ER) and anti-progesterone receptor (PR) antibodies. The cases were selected to represent each of the various histologic types: intraductal carcinoma (N=12), grade I invasive ductal carcinoma (N=15), grade II invasive ductal carcinoma (N=15), grade III invasive ductal carcinoma (N=15), tubular carcinoma (N=8), lobular carcinoma (N=10), and medullary carcinoma (N=10). The ductal breast carcinomas were graded I, II and III based on the Scarff-Bloom and Richardson grading system modified by Elston and Ellis. One slide containing at least 1000 neoplastic cells was examined in each case. ER, PR, p63, p53 and EBNA-1 were positive in 60, 40, 11.8, 21.2 and 37.6% of carcinomas, respectively. There was a correlation between EBNA-1 and p63 expression (P<0.001), but not between EBNA-1 and p53 (P=0.10). These data suggest a possible role for p63 in the mammary tumorigenesis associated with Epstein-Barr virus infection.
- Subjects :
- Adult
Aged
Biomarkers, Tumor
Breast Neoplasms metabolism
Carcinoma, Ductal, Breast genetics
Carcinoma, Ductal, Breast metabolism
Carcinoma, Ductal, Breast virology
DNA-Binding Proteins
Female
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Humans
Immunohistochemistry
Middle Aged
Receptors, Estrogen analysis
Receptors, Progesterone analysis
Transcription Factors
Tumor Suppressor Proteins
Breast Neoplasms genetics
Breast Neoplasms virology
Epstein-Barr Virus Nuclear Antigens genetics
Herpesvirus 4, Human isolation & purification
Phosphoproteins genetics
Trans-Activators genetics
Tumor Suppressor Protein p53 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0100-879X
- Volume :
- 37
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
- Publication Type :
- Academic Journal
- Accession number :
- 14689049
- Full Text :
- https://doi.org/10.1590/s0100-879x2004000100013