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Vaccinia virus recombinant expressing gene of tick-borne encephalitis virus non-structural NS1 protein elicits protective activity in mice.
- Source :
-
Immunology letters [Immunol Lett] 2003 Dec 15; Vol. 90 (2-3), pp. 161-3. - Publication Year :
- 2003
-
Abstract
- A vaccinia virus recombinant containing the non-structural tick-borne encephalitis virus (TBEV) NS1 gene was developed. The recombinant expressed native dimeric form of the NS1 protein in infected cells and protected mice against lethal infection with TBEV.
- Subjects :
- Animals
Antibodies, Viral immunology
Cell Line
Encephalitis Viruses, Tick-Borne genetics
Encephalitis, Tick-Borne virology
Mice
Mice, Inbred BALB C
Radioimmunoprecipitation Assay
Survival Rate
Viral Nonstructural Proteins genetics
Viral Vaccines immunology
Encephalitis Viruses, Tick-Borne immunology
Encephalitis, Tick-Borne immunology
Encephalitis, Tick-Borne prevention & control
Vaccinia virus genetics
Viral Nonstructural Proteins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-2478
- Volume :
- 90
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Immunology letters
- Publication Type :
- Academic Journal
- Accession number :
- 14687719
- Full Text :
- https://doi.org/10.1016/j.imlet.2003.09.002