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Topical cyclosporine A and corneal wound healing.
- Source :
-
Cornea [Cornea] 1992 Nov; Vol. 11 (6), pp. 546-52. - Publication Year :
- 1992
-
Abstract
- The effect of 2% topical cyclosporine A (CsA) ointment on corneal epithelial and stromal wound healing was evaluated in a masked, placebo-controlled study in rabbits. The difference in epithelial would healing rate in the treatment and placebo group was not statistically significant. There was also no difference in the values of bursting strength of 2-mm central penetrating wounds and in the measurement of hydroxyproline content in the central corneal buttons from the wounded area in both the groups. Clinical evaluation of the quality of regenerating epithelium, stromal edema, haze, and iritis did not reveal a difference between the two groups. There was a significantly higher incidence of conjunctival injection in the CsA-treated group. We conclude that topical cyclosporine A 2% does not significantly inhibit epithelial or stromal corneal wound healing.
- Subjects :
- Animals
Cell Division
Cornea metabolism
Cornea physiopathology
Corneal Edema drug therapy
Corneal Edema metabolism
Corneal Edema physiopathology
Corneal Stroma metabolism
Corneal Stroma physiopathology
Double-Blind Method
Epithelium
Hydroxyproline metabolism
Iritis drug therapy
Ointments
Placebos
Rabbits
Randomized Controlled Trials as Topic
Cornea drug effects
Corneal Stroma drug effects
Cyclosporine administration & dosage
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0277-3740
- Volume :
- 11
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cornea
- Publication Type :
- Academic Journal
- Accession number :
- 1468217
- Full Text :
- https://doi.org/10.1097/00003226-199211000-00011