Back to Search
Start Over
Is impairment of ischaemic preconditioning by sulfonylurea drugs clinically important?
- Source :
-
Heart (British Cardiac Society) [Heart] 2004 Jan; Vol. 90 (1), pp. 9-12. - Publication Year :
- 2004
-
Abstract
- In the UGDP study, published in the 1970s, a high incidence of cardiovascular mortality was found in patients treated with the sulfonylurea agent tolbutamide. Impaired ischaemic preconditioning is presumed to be the most important mechanism for the excess cardiovascular mortality observed. However, as tolbutamide has only a low affinity for cardiac sulfonylurea receptors, interference with ischaemic preconditioning seems unlikely to account for this excess mortality. Several smaller studies also failed to establish a definite link between sulfonylurea treatment before acute myocardial infarction and in-hospital mortality. However, when the myocardium becomes exposed to repeated or prolonged periods of ischaemia, ischaemic preconditioning may become clinically important. Myocardial ischaemia can also develop during emergency or elective angioplasty and during coronary bypass surgery. Therefore discontinuation of sulfonylurea treatment should be considered in these circumstances.
- Subjects :
- Animals
Catheterization methods
Diabetes Mellitus, Type 2 drug therapy
Diabetes Mellitus, Type 2 mortality
Humans
Hypoglycemic Agents therapeutic use
Models, Biological
Myocardial Ischemia mortality
Randomized Controlled Trials as Topic
Tolbutamide adverse effects
Tolbutamide therapeutic use
Cardiovascular Agents therapeutic use
Hypoglycemic Agents adverse effects
Ischemic Preconditioning, Myocardial methods
Myocardial Ischemia therapy
Sulfonylurea Compounds adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1468-201X
- Volume :
- 90
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Heart (British Cardiac Society)
- Publication Type :
- Academic Journal
- Accession number :
- 14676228
- Full Text :
- https://doi.org/10.1136/heart.90.1.9