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Anti-neuronal autoantibody in Hashimoto's encephalopathy: neuropathological, immunohistochemical, and biochemical analysis of two patients.
- Source :
-
Journal of the neurological sciences [J Neurol Sci] 2004 Jan 15; Vol. 217 (1), pp. 7-12. - Publication Year :
- 2004
-
Abstract
- Hashimoto's encephalopathy (HE) is thought to be caused by disorders of immune mechanisms. Although immunologically mediated central nervous system vasculitis or unidentified anti-neuronal autoantibodies have been suspected of causing HE, its pathogenesis is still unclear. For the study presented here, two patients with typical clinical and laboratory/electrophysiological findings of HE were analyzed to clarify the role of anti-neuronal autoantibodies in the pathogenesis of HE. The autopsied brain of one of the patients was histopathologically examined. For Western blotting analysis and immunohistochemistry, serum and purified immunoglobulin G obtained from the other patient were used. Autopsy revealed no evidence of central nervous system vasculitis or other abnormal findings in the brain. The patient's serum contained an anti-neuronal autoantibody that immunohistochemically labeled neurons of mouse and human cerebral cortices and reacted with the 36-kDa antigenic protein present in a soluble fraction obtained from human cerebral cortex. Our results indicate that anti-neuronal autoantibodies may be associated with the pathogenesis of HE.
- Subjects :
- Animals
Autoantibodies blood
Blotting, Western methods
Brain Diseases blood
Brain Diseases etiology
Humans
Immunoglobulin G blood
Immunoglobulin G immunology
Immunohistochemistry methods
Male
Mice
Mice, Inbred BALB C
Middle Aged
Thyroiditis, Autoimmune blood
Thyroiditis, Autoimmune complications
Autoantibodies immunology
Brain Diseases immunology
Neurons immunology
Thyroiditis, Autoimmune immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-510X
- Volume :
- 217
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of the neurological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 14675602
- Full Text :
- https://doi.org/10.1016/j.jns.2003.08.005