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DDTC, a metabolite of disulfiram, reduces the stimulating effect on ethanol's locomotor activity in mice.
- Source :
-
Psychopharmacology bulletin [Psychopharmacol Bull] 2003 Spring; Vol. 37 (2), pp. 113-9. - Publication Year :
- 2003
-
Abstract
- To investigate how diethyldithiocarbamate (DDTC) affects the stimulating effect of ethanol on open-field locomotion, mice were pretreated with different doses of DDTC 8 hours prior to ethanol. The effect of DDTC and saline on different ethanol doses was analyzed. DDTC reduces ethanol-induced locomotor activity in a dose-dependent manner, not the spontaneous locomotor activity. Aldehyde dehydrogenase might influence psychopharmacological effects of ethanol.
- Subjects :
- Alcohol Deterrents pharmacokinetics
Animals
Disulfiram pharmacokinetics
Dose-Response Relationship, Drug
Male
Mice
Alcohol Deterrents pharmacology
Central Nervous System Depressants pharmacology
Disulfiram pharmacology
Ditiocarb pharmacology
Ethanol antagonists & inhibitors
Ethanol pharmacology
Motor Activity drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0048-5764
- Volume :
- 37
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Psychopharmacology bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 14674371