The p210BCR-ABL tyrosine kinase of chronic myeloid leukemia causes resistance to radio-induced apoptotic death by inhibiting the proapoptotic BAX gene.

Subjects

Subjects :

Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive enzymology
Proto-Oncogene Proteins antagonists & inhibitors
RNA, Messenger analysis
Radiation, Ionizing
bcl-2-Associated X Protein
Apoptosis radiation effects
Fusion Proteins, bcr-abl physiology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive pathology
Proto-Oncogene Proteins genetics
Proto-Oncogene Proteins c-bcl-2

Details

Language :

English

ISSN :

0887-6924

Volume :

18

Issue :

2

Database :

MEDLINE

Journal :

Leukemia

Publication Type :

Academic Journal

Accession number :

14671649

Full Text :

https://doi.org/10.1038/sj.leu.2403207