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Human T-cell Lymphotropic Virus types I and II (HTLV-I/II) in French Guiana: clinical and molecular epidemiology.
- Source :
-
Cadernos de saude publica [Cad Saude Publica] 2003 Sep-Oct; Vol. 19 (5), pp. 1227-40. Date of Electronic Publication: 2003 Dec 02. - Publication Year :
- 2003
-
Abstract
- We review here the epidemiological studies performed by our group on human retrovirus HTLV-I and HTLV-II infections and the associated diseases in French Guiana since 1984. French Guiana is an overseas French administrative district located between Brazil and Surinam. Its population is characterized by a large variety of ethnic groups, including several populations of African origin and various populations of Amerindian origin. Several epidemiological studies of large samples of pregnant women and in remote villages showed that HTLV-I is highly endemic in this area but is restricted to groups of African origin, especially the Noir-Marrons. In this endemic population, the results of segregation analysis in a genetic epidemiological study were consistent with the presence of a dominant major gene predisposing to HTLV-I infection, especially in children. In contrast, HTLV-II infection appears to be rare in French Guiana, having been found in only a few individuals of Brazilian origin. From a molecular point of view, the HTLV-I strains present in the Noir-Marrons, Creoles and Amerindians appear to originate from Africa, as they belong to the large cosmopolitan molecular subtype A.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Endemic Diseases
Female
French Guiana epidemiology
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Pregnancy
Prevalence
Risk Factors
HTLV-I Infections epidemiology
HTLV-II Infections epidemiology
Human T-lymphotropic virus 1 genetics
Human T-lymphotropic virus 2 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0102-311X
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cadernos de saude publica
- Publication Type :
- Academic Journal
- Accession number :
- 14666205
- Full Text :
- https://doi.org/10.1590/s0102-311x2003000500002