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Aqueous oxygen attenuation of reperfusion microvascular ischemia in a canine model of myocardial infarction.
- Source :
-
ASAIO journal (American Society for Artificial Internal Organs : 1992) [ASAIO J] 2003 Nov-Dec; Vol. 49 (6), pp. 716-20. - Publication Year :
- 2003
-
Abstract
- Uncorrected microvascular ischemia may contribute to left ventricular impairment during reperfusion after prolonged coronary artery occlusion. Attenuation of such ischemia in microvessels with impaired erythrocyte flow may require delivery of oxygen at high levels in plasma. Intraarterial infusion of aqueous oxygen (AO) can be used in a site specific manner to achieve hyperoxemic levels of oxygenation in the perfusate. With this new approach, the hypothesis was tested that reperfusion microvascular ischemia can be attenuated. After a 90 min coronary balloon occlusion in a canine model, AO hyperoxemic intracoronary perfusion was performed for 90 min after a 30 min period of autoreperfusion. Control groups consisted of normoxemic reperfusion, both passive (autoreperfusion) and active (roller pump). A significant improvement in left ventricular ejection fraction (p < 0.05) at 2 hr of reperfusion was noted only in the AO hyperoxemia group (17 +/- 6% by two dimensional echo), without a significant reduction in the improvement 1 hr after termination of treatment. During AO hyperoxemic perfusion, ECG ST segment isoelectric deviation normalized, and frequency of ventricular premature contractions was significantly reduced, in contrast to the autoreperfusion control group (p < 0.05). Microvascular blood flow, measured as the ischemic/normal left ventricular segment ratio by radiolabeled microspheres immediately after AO hyperoxemic perfusion, was double the value of the autoreperfusion control group at 2 hr of reperfusion (p < 0.05). We conclude that reperfusion microvascular ischemia is attenuated by intracoronary AO hyperoxemic perfusion and acutely improves left ventricular function in this model.
- Subjects :
- Animals
Coronary Circulation drug effects
Disease Models, Animal
Dogs
Electrocardiography
Microcirculation drug effects
Myocardial Infarction diagnosis
Myocardial Ischemia diagnosis
Oxygen blood
Ventricular Function, Left drug effects
Myocardial Infarction drug therapy
Myocardial Ischemia drug therapy
Myocardial Reperfusion methods
Oxygen administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1058-2916
- Volume :
- 49
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- ASAIO journal (American Society for Artificial Internal Organs : 1992)
- Publication Type :
- Academic Journal
- Accession number :
- 14655741
- Full Text :
- https://doi.org/10.1097/01.mat.0000094665.72503.3c