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Relationship between fluvoxamine and stress barometer for nocturnal enuresis.
- Source :
-
Pediatrics international : official journal of the Japan Pediatric Society [Pediatr Int] 2003 Dec; Vol. 45 (6), pp. 688-91. - Publication Year :
- 2003
-
Abstract
- Background: It has been reported recently that fluvoxamine (a selective serotonin reuptake inhibitor) is effective and safe for children with monosymptomatic nocturnal enuresis (MNE). However, the exact mechanism by which fluvoxamine is beneficial in the treatment of MNE remains unknown. One possibility is that it controls emotional stress.<br />Methods: We divided children with MNE into primary MNE (n = 40) and secondary MNE (n = 7). We measured urinary 17-hydroxycorticosteroids (17-OHCS) and 17-ketosteroid sulfates (17-KS-S) as a stress barometer in children with MNE to evaluate adaptation to emotional stress before and during fluvoxamine treatment. We initially administered fluvoxamine at a dose of 25 mg at bedtime. If patients remained incontinent after 3 weeks, we increased the dose to 50 mg.<br />Results: Fluvoxamine was effective in 26 of 28 children (93%) with primary MNE and an abnormality of the stress barometer and in six of six children (100%) with secondary MNE and an abnormality of the stress barometer. Fluvoxamine was effective in only six of 12 children (50%) with primary MNE and normality of the stress barometer and was not effective in one child with secondary MNE and normality of the stress barometer.<br />Conclusions: The stress barometer is useful clinically for evaluating the therapeutic effect of fluvoxamine for children with MNE.
- Subjects :
- 17-Hydroxycorticosteroids urine
17-Ketosteroids urine
Adolescent
Biomarkers urine
Child
Enuresis psychology
Female
Humans
Male
Stress, Psychological diagnosis
Stress, Psychological drug therapy
Enuresis drug therapy
Fluvoxamine therapeutic use
Selective Serotonin Reuptake Inhibitors therapeutic use
Stress, Psychological complications
Subjects
Details
- Language :
- English
- ISSN :
- 1328-8067
- Volume :
- 45
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Pediatrics international : official journal of the Japan Pediatric Society
- Publication Type :
- Academic Journal
- Accession number :
- 14651542
- Full Text :
- https://doi.org/10.1111/j.1442-200x.2003.01802.x