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Efficient repair of DNA damage induced by heavy ion particles in meiotic prophase I nuclei of Caenorhabditis elegans.
- Source :
-
Journal of radiation research [J Radiat Res] 2003 Sep; Vol. 44 (3), pp. 271-6. - Publication Year :
- 2003
-
Abstract
- The effects of heavy ion particle irradiation on meiosis and reproductive development in the nematode Caenorhabditis elegans were studied. Meiotic pachytene nuclei are significantly resistant to particle irradiation by the heavy ions carbon and argon, as well as to X-rays, but not UV, whereas diplotene to diakinesis stage oocytes and early embryonic cells are not. Chromosomal abnormalities appear in mitotic cells and in maturing oocytes irradiated with heavy ion particles during the diplotene to the early diakinesis stages, but not in oocytes irradiated during the pachytene stage. The pachytene nuclei of ced-3 mutants, which are defective in apoptosis, are similarly resistant to ionizing radiation, but pachytene nuclei depleted for Ce-atl-1 (ataxia-telangiectasia like 1) or Ce-rdh-1/rad-51 are more sensitive. Pachytene nuclei thus appear to effectively repair heavy ion-induced DNA damage by the meiotic homologous recombination system.
- Subjects :
- Animals
Ataxia Telangiectasia Mutated Proteins
Caenorhabditis elegans genetics
Caenorhabditis elegans metabolism
Caenorhabditis elegans Proteins
Dose-Response Relationship, Radiation
Meiosis genetics
Meiosis radiation effects
Phosphotransferases deficiency
Radiation Dosage
Radiation Tolerance genetics
Recombination, Genetic radiation effects
Ultraviolet Rays
X-Rays
Caenorhabditis elegans radiation effects
DNA radiation effects
DNA Damage genetics
DNA Repair physiology
Heavy Ions
Oogenesis radiation effects
Prophase genetics
Prophase radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 0449-3060
- Volume :
- 44
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of radiation research
- Publication Type :
- Academic Journal
- Accession number :
- 14646232
- Full Text :
- https://doi.org/10.1269/jrr.44.271