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Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2003 Dec 15; Vol. 13 (24), pp. 4477-80. - Publication Year :
- 2003
-
Abstract
- A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta) has proven to be effective in clinical trials for the treatment of depression.
- Subjects :
- Antidepressive Agents chemical synthesis
Antidepressive Agents therapeutic use
Binding Sites
Clinical Trials as Topic
Depressive Disorder drug therapy
Duloxetine Hydrochloride
Humans
Kinetics
Selective Serotonin Reuptake Inhibitors chemical synthesis
Selective Serotonin Reuptake Inhibitors pharmacology
Structure-Activity Relationship
Thiophenes therapeutic use
Norepinephrine antagonists & inhibitors
Selective Serotonin Reuptake Inhibitors chemistry
Thiophenes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 13
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 14643350
- Full Text :
- https://doi.org/10.1016/j.bmcl.2003.08.079